Successful management of metachronous dual primary esophageal carcinomas: first report of consecutive adenoid cystic carcinoma and squamous cell carcinoma with exceptional treatment outcome – a case report

Rákkutatás · Esophageal cancer

This case illustrates that SPMs may arise outside irradiated regions after ACC treatment, excluding radiation‑induced carcinogenesis.

A 58‑year‑old male with esophageal adenoid cystic carcinoma (ACC) underwent surgical resection followed by adjuvant radiotherapy (50 Gy/25 fractions). Sixteen months later, a metachronous cervical esophageal squamous cell carcinoma (SCC) was detected outside the prior radiation field and was successfully treated with definitive chemoradiotherapy (60 Gy/28 fractions with concurrent S‑1). At March 2026 follow‑up, the patient remained disease‑free.

The report demonstrates that a metachronous second primary esophageal cancer can be effectively managed with curative intent even after prior radiotherapy, highlighting the importance of comprehensive surveillance and multidisciplinary treatment planning for rare esophageal malignancies.

Bizonyítékszint: Korai humán adat. Kis vagy feltáró emberi adat.

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