Case Report: Small bowel metastasis from esophageal squamous cell carcinoma: a case series and systematic review of clinical characteristics, tropism, and survival outcomes
Our systematic review and case series reveal that small bowel metastasis from esophageal squamous cell carcinoma is a rare but aggressive event occurring in advanced disease, with a median survival of only 6 months, highlighting the importance of early detection and multimodal treatment.
Small bowel metastasis from primary esophageal carcinoma is a rare occurrence that usually marks advanced disease and presents with non‑specific abdominal symptoms. In this report we describe a 60‑year‑old man who developed small bowel obstruction due to metastatic esophageal squamous cell carcinoma (SCC). After surgical resection and multimodal therapy with camrelizumab, nab‑paclitaxel and cisplatin, he achieved a partial response and a nine‑month overall survival. A systematic review of 23 published cases (including this one) showed a male predominance (82.6 %), a median age at small bowel metastasis of 62 years, a predominance of SCC (82.6 %) and a median survival of only 6 months. The data underscore that early consideration of metastatic spread, prompt diagnostic confirmation by histopathology/IHC, and a multidisciplinary therapeutic approach can improve outcomes in this challenging setting.
Because small bowel metastasis from esophageal SCC is often overlooked, leading to diagnostic delays and suboptimal management; raising awareness can improve early detection and potentially extend survival.
Bizonyítékszint: Korai humán adat. Kis vagy feltáró emberi adat.
Kapcsolódó jelek
- Esophageal Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf
- Clinical Trials Update in Resectable Esophageal Cancer
- Advances in targeted therapy for esophageal cancer
- A review of esophageal cancer research: emerging trends, progress and perspectives
- An esophageal cancer clinical trial - ES3