Betulinic Acid Extracted from Guava (Psidium guajava L.) Leaves Inhibits Human Cholangiocarcinoma Cell Metastasis by Activating E-cadherin and Inhibiting MMP-9 and VEGF
BA effectively reduced metastasis and invasion in HuCCA cells.
Betulinic acid (BA), a pentacyclic triterpene glycoside found in the leaves of guava (Psidium guajava L.), exhibits various biological activities, including inhibition of cancer progression in multiple cancer cell types. However, the mechanism of action of BA in human cholangiocarcinoma (HuCCA) invasion and metastasis remains unclear.
Demonstrates that BA can inhibit metastasis of cholangiocarcinoma by upregulating E‑cadherin and downregulating MMP‑9 and VEGF, indicating a potential therapeutic strategy.
Bizonyítékszint: Korai humán adat. Kis vagy feltáró emberi adat.
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