Scientists discover why cancer drugs don’t work for everyone
Scientists have uncovered a hidden reason why cancer treatments don’t work equally well for everyone.
Scientists have uncovered a hidden reason why cancer treatments don’t work equally well for everyone. Certain drugs can become trapped inside lysosomes within tumor cells, forming slow‑release reservoirs that create uneven drug distribution. This means some cancer cells are heavily exposed while others are barely affected. Understanding this process could help doctors better tailor treatments and improve outcomes.
The uneven distribution of therapeutic agents within tumors can lead to incomplete cell kill, allowing resistant cells to survive and eventually cause relapse. Insights into the intracellular mechanisms that create these ‘hotspots’ may enable the design of more effective dosing regimens and drug formulations.
Evidence level: Klinikai vizsgálat. Formális klinikai vizsgálati eredmény.
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