Esophageal Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf

Cancer research · Esophageal cancer

A Radiation Therapy Oncology Group randomized trial (RTOG-8501) of chemotherapy and radiation therapy versus radiation therapy alone resulted in an improvement in 5-year survival for the combined modality group (27% vs. 0%).

Photodynamic therapy (PDT) is a localized treatment for esophageal stenosis and dysphagia in advanced cancer. This Phase II trial evaluated the efficacy and safety of Cosiporfin sodium (DVDMS)-mediated PDT for dysphagia in advanced esophageal cancer. Twenty patients were enrolled in the 102 J/cm 24 h group, six in the 200 J/cm 24 h group, and four in the 150 J/cm 18 h group. Two patients experienced dose‑limiting toxicities (one upper abdominal pain and one non‑cardiac chest pain). Common adverse events included non‑cardiac chest pain and anemia. The esophageal overall response rate was 40.0% on day 28. Median duration of esophageal response was 4.86 months and median overall survival was 9.51 months. DVDMS-mediated PDT demonstrated acceptable safety and sustained efficacy in improving esophageal stenosis and dysphagia in advanced esophageal cancer.

This evidence supports the use of combined chemoradiation to improve survival outcomes in patients with esophageal cancer.

Evidence level: Számítógépes vagy elméleti. Modellből vagy adatbányászatból származó jel.

Original source

Related signals