Kutatási jelek – Signal Engine

• Reduced levels of ITGB1 cause activation of p38MAPK-ERK-LYN axis of BCR::ABL1 signaling despite inactivation of the oncoprotein by imatinib – novel resistance mechanism in blast crisis of chronic myeloid leukemia unraveled — Chronic myeloid leukemia
• Advances in multiple myeloma: key updates from the ASH 2025 meeting — Multiple myeloma
• Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy — Cervical cancer
• Biomarkers & Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review & Meta‑Analysis — Head and neck squamous cell carcinoma
• TP53 in myeloid neoplasms — Acute myeloid leukemia
• Management of BK Polyomavirus in a Kidney Transplant Recipient With Primary Myelofibrosis on JAK-2 Inhibition — A Case Report and Literature Review — methylprednisolone
• Toward Targeted Treatment Strategies for Mantle Cell Lymphoma — Mantle cell lymphoma
• Genomic landscape of cholangiocarcinoma in India: ethnic variants and implications for targeted therapy — Cholangiocarcinoma
• SEOM‑TTCC clinical guideline for nasopharyngeal carcinoma (update 2025) — Nasopharyngeal carcinoma
• Diagnosis and Management of Adrenocortical Carcinoma — Adrenocortical carcinoma
• Cross-Platform Gene Signature to Predict Survival Outcomes for Nasopharyngeal Carcinoma — Nasopharyngeal carcinoma
• DUSP5 suppresses esophageal squamous cell carcinoma by counteracting macrophage-derived AREG-ERK1/2 signaling and disrupting an oncogenic ERK1/2-ELK1-DUSP5 feedback circuitry — Esophageal cancer
• Machine Learning for Thyroid Cancer Detection, Presence of Metastasis, and Recurrence Predictions—A Scoping Review — Thyroid cancer
• Gastrointestinal Stromal Tumor: History, Molecular Subtypes, and Risk Stratification — Gastrointestinal stromal tumor
• The clinical trial landscape of osteosarcoma: integrating trial data, immunotherapeutic trends, and biomarker insights — Osteosarcoma
• Uterine myxoid leiomyosarcoma complicated by pulmonary embolism: a case report with a systematic literature review — Endometrial cancer
• Chinese guidelines for HER2-targeted therapy in gastric and gastroesophageal junction adenocarcinoma (2025 Edition) — Gastric cancer
• Cancer-associated fibroblasts promote osimertinib resistance in non‑small cell lung cancer cells via METTL1‑mediated NET1 m^7G modification — NSCLC
• Frontiers | Advanced ALK‑EML4 fusion‑positive non-small cell lung cancer with intraspinal metastases: a case report — NSCLC
• Gastrointestinal Stromal Tumors — Gastrointestinal stromal tumor