Regional Differences in the Clinical Presentation of Registry-Recorded Renal Cell Carcinoma and Area-Level Healthcare Resource Indicators: A Multicenter Study in Miyazaki, Japan

Cancer research · Renal cell carcinoma

The adjusted odds ratio for predefined local symptoms in the Northern area versus Central/Southern was 2.30 (95% CI, 1.39–3.81).

A retrospective descriptive observational analysis of prospectively collected data from the Miyazaki Urological Cancer Database (MUCD) examined regional differences in clinical presentation of renal cell carcinoma (RCC) and area-level healthcare resource indicators across Central/Southern, Western, and Northern regions of Miyazaki Prefecture. Among 540 patients, presentation with predefined local symptoms occurred in 18.6%, 19.0%, and 34.1% in Central/Southern, Western, and Northern areas, respectively. The adjusted odds ratio for predefined local symptoms in the Northern area versus Central/Southern was 2.30 (95% CI, 1.39–3.81). Median tumor size was 3.8, 4.4, and 5.0 cm; the adjusted mean difference for Northern versus Central/Southern was 1.24 cm (95% CI, 0.65–1.82). Clinical M1 disease was recorded in 10.2%, 12.1%, and 19.8%; the Holm‑adjusted p‑value for Northern versus Central/Southern was 0.082.

Higher odds of presenting with local symptoms and larger tumors in the Northern region suggest that limited regional healthcare resources may contribute to later diagnosis of renal cell carcinoma, potentially impacting treatment outcomes and survival.

Evidence level: Korai humán adat. Kis vagy feltáró emberi adat.

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