Anal Cancer
Anal cancer incidence is increasing among HIV-positive patients.
Anal cancer is an uncommon malignancy in which malignant cells are found in the anus. Cancer of the outer anus is more frequent in men, whereas cancer of the inner part of the rectum (the anal canal) is more frequent in women.
HIV-positive individuals on highly active antiretroviral therapy are living longer, thereby increasing their risk for high-risk human papillomavirus (HR‑HPV) infection and subsequent HPV‑related anal cancers. Accurate screening and early detection are therefore essential to reduce morbidity and mortality in this high‑risk population.
Evidence level: Állatkísérletes. Állatmodellben vizsgálták.
Related signals
- Clinical Outcomes, Patterns of Failure, and Salvage Therapies of a Large Modern Cohort of Patients With Anal Squamous Cell Carcinoma Treated With Definitive-Intent Intensity‑Modulated Radiation Therapy
- Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer
- Advancements in Immunotherapy for Anal Cancer Treatment
- Background and Current Treatment of Squamous Cell Carcinoma of the Anus
- Genotyping and Cytology Co-Testing for Anal Cancer Screening: Exploratory Evaluation of Cumulative HPV Genotype Burden