A retrospective cohort study of surgery for adrenocortical carcinoma in a tertiary endocrine surgery unit

Rákkutatás · Adrenocortical carcinoma

A retrospective cohort study of surgery for adrenocortical carcinoma in a tertiary endocrine surgery unit.

The study examines clinical outcomes of patients with adrenocortical carcinoma (ACC) who underwent surgery over 14 years in an endocrine surgery unit. Demographic, clinical, pathological and follow‑up data were collected on consecutive patients who underwent surgery for ACC or cortical tumours of uncertain malignant potential (UMP) and patients with a clinical diagnosis of ACC. Of 48 patients, 32 had ACC confirmed on histology, 10 had a clinical diagnosis and 6 had UMPs. In the histological cohort (32 patients), 12 were men and 20 women with a median age of 53 years at first operation. ENSAT staging was I in 2, II in 18, III in 5, IV in 6 and unknown in 1. Complete resection was achieved in 16 patients. Adjuvant treatments included mitotane and external beam radiotherapy in 18 (56%) and 2 (6%) patients, respectively. Four patients (initial surgery outside this centre) had multiple operations. The median overall survival was 33 months (range 7–172) and median time to persistent or recurrent disease was 8 months (range 0–71). The study provides a contemporary perspective on epidemiology and practice in the management of ACC in the UK.

The research provides contemporary data on the outcomes of surgical treatment for adrenocortical carcinoma, a rare endocrine cancer, helping clinicians assess prognosis and adjuvant therapy options.

Bizonyítékszint: Klinikai vizsgálat. Formális klinikai vizsgálati eredmény.

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