Delivering Immunotherapy for Head and Neck Squamous Cell Carcinoma in the Presence of Tumor Microbiome
Bacteria located within head and neck squamous cell carcinoma tumors can impede the efficacy of immunotherapy by recruiting myeloid cells that suppress T‑cell responses, suggesting that antibiotics may restore immunotherapy effectiveness.
The study explains why a previously successful immunotherapy‑radiation strategy failed in most head and neck cancer patients and identifies bacterial load as a key determinant of response, offering a potential method to overcome resistance.
Evidence level: Állatkísérletes. Állatmodellben vizsgálták.
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