HDACi induces apoptosis of osteosarcoma cells by inhibiting the MAPK pathway
HDACi induces apoptosis of osteosarcoma cells by inhibiting the MAPK pathway
Investigate the malignant biological effects of the histone deacetylase inhibitor (HDACi) in osteosarcoma (OS) and study the underlying mechanisms through mRNA sequencing. ... HDACi can significantly inhibit the malignant biological abilities of OS cells and induce apoptosis in OS cells by suppressing the MAPK/ERK pathway.
Osteosarcoma is highly aggressive with poor prognosis; targeting epigenetic regulators such as HDACs may provide a novel therapeutic avenue.
Bizonyítékszint: Számítógépes vagy elméleti. Modellből vagy adatbányászatból származó jel.
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