How Traditional Chinese Medicine Works: Biological Mechanisms and Clinical Evidence for Hepatocellular Carcinoma Treatment
Curcumin inhibits HCC growth through MARCH1-mediated JAK2/STAT3 signaling regulation.
Hepatocellular carcinoma (HCC) is a malignant tumor with a high mortality rate globally, ranking among the top cancers in incidence and posing a serious human health threat. Traditional Chinese medicine (TCM) has attracted increasing interest for its potential role in the management of HCC. This review critically synthesizes the biological mechanisms and clinical application evidence of TCM extracts and classic formulas in HCC treatment, detailing their roles in inhibiting tumor growth, inducing apoptosis, enhancing immunity, and suppressing angiogenesis.
Curcumin is a naturally occurring compound that can modulate key oncogenic pathways in hepatocellular carcinoma, offering a potential therapeutic approach with a favorable safety profile.
Evidence level: Sejtvonalas. Laboratóriumi sejtekben vizsgálták.
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