Declines in cervical cancer incidence among young women in the United States

Cancer research · Cervical cancer

Cervical cancer incidence has been declining among adolescents and young adult women in the United States, especially in recent years, reflecting the population‑level impact of HPV vaccination and improved screening practices.

We calculated age-standardized cervical cancer incidence rates and trends by histologic type among women aged 15–29 years, using cancer registry data covering approximately 99% of the U.S. population. Incidence rates for cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) decreased significantly during 1999–2022 in all age groups. Among women aged 15–20 years, cervical SCC rates were stable from 1999 to 2010 but declined substantially by 24.2% per year from 2010 to 2022. These findings show that cervical cancer incidence has declined among adolescents and young adult women in the United States, particularly in more recent years, highlighting the population-level impact of cervical cancer prevention measures.

The sustained decline in cervical cancer incidence among younger women provides population-level evidence that HPV vaccination and optimized screening strategies are effective in reducing the disease burden, supporting ongoing public health initiatives to further increase vaccination coverage and screening uptake.

Evidence level: Korai humán adat. Kis vagy feltáró emberi adat.

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