Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty‑first century

Rákkutatás · Chronic lymphocytic leukemia

Survival for chronic lymphocytic leukemia (CLL) patients over the 2009‑2011 period is high, with 5‑year relative survival exceeding 80 % and 10‑year relative survival around 60 % in both Germany and the USA, but older patients and men experience lower survival rates.

Background: Population‑based studies in the US and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia (CLL). This study examines survival for patients diagnosed with CLL in Germany (1997‑2011) and compares it with US data. Methods: Data were extracted from 12 German cancer registries and the US SEER13 database; 5‑ and 10‑year relative survival estimates were calculated using period analysis. Results: In 2009‑2011, 5‑year relative survival was 80.2 % in Germany and 82.4 % in the USA; 10‑year relative survival was 59.5 % in Germany and 64.7 % in the USA. Survival increased slightly over time, especially for patients aged 45‑54. Men and older patients (75+) had lower survival rates. Conclusions: 5‑year survival for CLL patients is good but 10‑year survival remains markedly lower, particularly among older patients, underscoring the need for strategies to improve outcomes for this group.

Improved survival estimates help clinicians and policymakers understand the current prognosis for CLL, guide resource allocation, and highlight gaps—particularly for older patients—where novel therapies could have the greatest impact.

Bizonyítékszint: Korai humán adat. Kis vagy feltáró emberi adat.

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