Update on the Treatment of Non‑Small Cell Lung Carcinoma (NSCLC)
dacomitinib is effective and safe, with no serious adverse effects in patients with metastatic NSCLC bearing EGFR activating mutations
Non‑small cell lung carcinoma (NSCLC) is a prominent type, with an 85–90% incidence in all lung cancer cases. The evidence for a particular therapy strategy for people with NSCLC is still inadequate. This review evaluates NSCLC therapies that have passed phase IV trials, emphasizing their efficiency and adverse effects. Crucial therapeutic approaches, including dacomitinib, lorlatinib, durvalumab, osimertinib, and rivaroxban, are discussed, highlighting their mechanisms of action, uses, and adverse effects. Immune checkpoint medications are recommended because of their specific activity and minimal adverse reactions. The review also investigates cooperation therapies, such as targeting immune checkpoint inhibitors and hemostasis, alongside chemotherapy, as they offer potential for future therapies. However, further research is needed to improve the safety and efficacy of current treatments, and to explore novel ways to achieve better long‑term outcomes.
Effective and safe targeted therapies such as dacomitinib can significantly improve survival and quality of life in NSCLC patients with EGFR‑activating mutations, addressing a major unmet need in advanced lung cancer management.
Evidence level: Megerősített klinikai bizonyíték. Több vagy erősebb humán vizsgálat támogatja.
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