Cancer drug resistance: an evolving paradigm
Tumour resistance can be intrinsic or acquired during treatment by various therapy-induced adaptive responses.
Resistance to chemotherapy and molecularly targeted therapies is a major problem facing current cancer research. The mechanisms of resistance to ‘classical’ cytotoxic chemotherapeutics and to therapies that are designed to be selective for specific molecular targets share many features, such as alterations in the drug target, activation of prosurvival pathways and ineffective induction of cell death. With the increasing arsenal of anticancer agents, improving preclinical models and the advent of powerful high‑throughput screening techniques, there are now unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive biomarkers to enable patient stratification.
Understanding the molecular basis of drug resistance is essential for developing rational drug combinations and predictive biomarkers that can guide patient‑specific therapies, thereby improving clinical outcomes in cancer treatment.
Bizonyítékszint: Klinikai vizsgálat. Formális klinikai vizsgálati eredmény.
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