Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors.
A biobank of patient‑derived HCC organoids coupled with a high‑throughput screening platform identified over 1,600 compounds with antitumor activity and rationally designed regorafenib‑based doublets and triplets that enhance efficacy across heterogeneous tumors, supporting combination therapy strategies.
Bizonyítékszint: Sejtvonalas. Laboratóriumi sejtekben vizsgálták.
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