The role of TP53 mutations in oral cancer: molecular mechanisms and prognostic implications
TP53 mutations are strongly associated with advanced tumor stage, lymph node metastasis, therapy resistance, and poor prognosis in oral squamous cell carcinoma.
A comprehensive review highlights how TP53 mutations contribute to oral cancer development, treatment resistance, and poor patient outcomes. The study summarizes emerging therapeutic approaches, including mutant p53 reactivation, synthetic lethality, and immunotherapy‑based strategies, providing new perspectives for precision medicine in oral cancer.
TP53 mutations are one of the most frequent genetic alterations in oral cancer, driving tumor progression and conferring resistance to conventional therapies. Identifying TP53 status can inform risk stratification, prognosis, and the development of targeted treatments that may improve survival and reduce recurrence.
Evidence level: Feltételezés / hírjelzés. Nincs önálló tudományos bizonyíték.
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