Optimized Dosing of Regorafenib in Patients With Metastatic Colorectal Cancer
The regorafenib dose‑optimization study (ReDOS) demonstrated that starting at a lower dose of 80 mg daily followed by dose escalation to the standard 160 mg daily improved tolerability and maintained efficacy in patients with metastatic colorectal cancer.
This review provides a clinically relevant appraisal of the regorafenib dose‑optimization study (ReDOS) and the implications for patient management from the perspective of oncologists, advanced practice providers, and pharmacists.
Dose optimisation can reduce toxicity, improve patient adherence, and preserve clinical outcomes, addressing a critical need for safe and effective therapy in metastatic colorectal cancer.
Evidence level: Klinikai vizsgálat. Formális klinikai vizsgálati eredmény.
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