Characterization and functional analysis of miRNAs in Salvia miltiorrhiza-isolated exosome-like nanoparticles for gastric cancer treatment
Exosome‑like nanoparticles (ELNs) were successfully purified from Salvia miltiorrhiza Bunge (Danshen) utilizing ultracentrifugation.
Exosome-like nanoparticles (ELNs) isolated from Salvia miltiorrhiza Bunge (Danshen) exert anti‑tumor effects on human gastric cancer (GC) cells (HGC‑27) by inhibiting proliferation, migration, and colony formation while promoting apoptosis. MiRNA sequencing identified abundant miRNAs within these ELNs that may serve as therapeutic targets for GC.
Demonstrating that plant‑derived ELNs contain functional miRNAs capable of suppressing gastric cancer cell growth and invasiveness provides a novel, biocompatible platform for developing anti‑cancer therapeutics.
Bizonyítékszint: Állatkísérletes. Állatmodellben vizsgálták.
Kapcsolódó jelek
- Precision medicine in gastric cancer
- Gastric cancer
- DESTINY‑Gastric05 Phase 3 Trial of ENHERTU Initiated in Patients with Previously Untreated HER2 Positive Advanced Gastric Cancer
- Nivolumab/Chemo Yields Long-Term Survival in Advanced Gastric Cancers
- Current Treatment and Recent Progress in Gastric Cancer