Molecular Markers and Prior Treatment Inform Maintenance PARP Inhibition in Ovarian Cancer
Homologous recombination deficiency (HRD) status, BRCA mutational status, and prior bevacizumab (Avastin) treatment should be used to inform which PARP inhibitor—olaparib (Lynparza), rucaparib (Rubraca), or niraparib (Zejula)—a patient with ovarian cancer should receive in the frontline or recurrent maintenance settings
The sentence directly states how biomarker status directs maintenance PARP inhibitor selection in ovarian cancer, highlighting the clinical decision‑making process that the article discusses.
Bizonyítékszint: Klinikai vizsgálat. Formális klinikai vizsgálati eredmény.
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- Epithelial ovarian cancer: prevention, diagnosis, and treatment
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- Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements