Disparities in Uveal Melanoma: Patient Characteristics
Uveal melanoma is the most common intraocular malignancy in adults, and disparities in patient characteristics such as age, gender, race, and UV exposure significantly influence the incidence, metastatic risk, and survival outcomes.
Uveal melanoma is the most common intraocular malignancy in adults. Despite excellent rates of local control, half of all patients with uveal melanoma ultimately go on to develop fatal metastatic disease. This review focuses on disparities and differences in the underlying characteristics of the patients, and how these patient characteristics impact the development of metastasis and subsequent patient survival. Specifically, we detail disparities in epidemiology and risk factors as they relate to the development of primary uveal melanoma, to the development of metastasis, and to patient survival following metastasis.
Disparities in patient characteristics—such as age, gender, race, and UV exposure—affect the incidence, progression, and survival of uveal melanoma, underscoring the importance of personalized surveillance strategies and targeted interventions to reduce morbidity and mortality.
Bizonyítékszint: Sejtvonalas. Laboratóriumi sejtekben vizsgálták.
Kapcsolódó jelek
- Beyond the Five-Year Milestone: Long‑term Survivorship of Melanoma Patients Treated Off‑Trial with anti‑PD‑1
- Uveal Melanoma – Trials in Disease – Overview of Information and Clinical Research
- A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma
- Melanoma Research
- The Clinical Trial Landscape for Melanoma Therapies