Adenoid cystic carcinoma (ACC)
Adenoid cystic carcinoma (ACC) is a rare malignant cancer primarily affecting secretory glands, most commonly found in the major and minor salivary glands of the head and neck, but it can also appear in other areas such as the trachea, tongue, and breast.
Adenoid cystic carcinoma (ACC) is a rare malignant cancer of the secretory glands, most commonly arising in the major and minor salivary glands of the head and neck but also reported in the trachea, tongue, lacrimal gland, breast, skin and vulva. It predominantly affects women over 50, presents with slow‑growing painless masses, and is diagnosed by histologic examination. Treatment is mainly surgical, with radiotherapy in some cases; chemotherapy options are limited, though trials are evaluating paclitaxel and gemcitabine. The disease progresses slowly but can metastasise to lung and liver, resulting in poor long‑term survival.
Understanding the epidemiology, presentation, and limited treatment options for this rare cancer is essential for timely diagnosis, patient counseling, and guiding research toward more effective therapies.
Evidence level: Sejtvonalas. Laboratóriumi sejtekben vizsgálták.
Related signals
- Correction: Primary cutaneous adenoid cystic carcinoma of the right forearm: a case report and dermoscopic features
- A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug
- Deciphering the potential pathogeny of rare tracheal adenoid cystic carcinoma by single‑cell RNA‑sequencing
- DAY301 | Day One Biopharmaceuticals
- Completed Studies – Adenoid Cystic Carcinoma Research Foundation