Scientists create "smart" DNA drug that targets cancer cells with extreme precision
Scientists have built a “smart” DNA drug that can zero in on cancer cells with unprecedented accuracy.
Scientists have created a programmable DNA-based drug system that can identify cancer cells with extreme precision by detecting a specific combination of tumor markers and release drugs only at those sites. The system, built from short synthetic DNA strands, uses a two‑key logic gate that requires the presence of two distinct cancer markers to activate the delivery of toxic drugs, sparing healthy cells. Multiple drugs can be delivered simultaneously, potentially overcoming resistance. The study demonstrates a step toward responsive, self‑operating therapies that could be customized to individual patients.
The technology offers a new approach to targeted therapy, potentially improving treatment efficacy while reducing side effects, and may pave the way for customizable, programmable drugs that can adapt to a patient’s unique tumor biology.
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