SEOM‑GEMCAD‑TTD clinical guidelines for anal cancer (2025) - Clinical and Translational Oncology
Chemoradiotherapy with 5‑FU and mitomycin C (MMC) is the standard of care for early and locally advanced disease, while combination chemotherapy with a platinum‑containing compound and taxanes is the treatment of choice for metastatic disease.
Anal cancer is rare but increasingly common, currently accounting for 2% of all digestive neoplasms. Some 50% of anal cancers are diagnosed at the localized stage, 29% as locoregional disease, and 12% as metastatic disease. When clinical suspicion of anal cancer exists, histological confirmation, correct local staging with MRI and distant staging with thoraco‑abdominal CT, and management by a multidisciplinary team are mandatory. Chemoradiotherapy with 5‑FU and mitomycin C (MMC) is the standard of care for early and locally advanced disease, while combination chemotherapy with a platinum‑containing compound and taxanes is the treatment of choice for metastatic disease.
This sentence identifies the recommended standard therapy for both early/locoregional and metastatic anal cancer, guiding clinicians in selecting the appropriate treatment regimen.
Evidence level: Klinikai vizsgálat. Formális klinikai vizsgálati eredmény.
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