Total body irradiation versus chemotherapy before stem cell transplantation in children aged two to four with acute lymphoblastic leukemia—an EBMT pediatric diseases working party study
Total body irradiation versus chemotherapy before stem cell transplantation in children aged two to four with acute lymphoblastic leukemia
The study evaluates whether total body irradiation (TBI)-based conditioning or chemotherapy (CTx)-based conditioning provides better outcomes in children aged 2–4 years with acute lymphoblastic leukemia (ALL) undergoing allo‑hematopoietic stem cell transplantation, addressing the crucial balance between long‑term toxicity (e.g., subsequent malignant neoplasms) and disease control.
Evidence level: Sejtvonalas. Laboratóriumi sejtekben vizsgálták.
Related signals
- Acute Myeloid Leukemia Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf
- Recent advances on blinatumomab for acute lymphoblastic leukemia
- NCT05800210: Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Acute Lymphoblastic Leukemia
- Advancing the Diagnosis of Non‑Hodgkin Lymphoma Through Next‑Generation Sequencing in Developing Countries: An Evaluation of Progress — A Narrative Review
- Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)