Deciphering the potential pathogeny of rare tracheal adenoid cystic carcinoma by single‑cell RNA‑sequencing
Developing drugs that target MIF‑CD74 signaling pathways may lead to breakthroughs in the treatment of TACC
This study performs single‑cell RNA‑sequencing on tumor, adjacent tissue, and blood from a patient with tracheal adenoid cystic carcinoma (TACC). Analysis identified distinct epithelial, immune, and stromal clusters, revealing that ciliated epithelial cells with stem‑cell markers likely represent the tumor’s origin. Immunophenotyping and multiplex immunohistochemistry confirmed aberrant expression of CD68, CD74, CD44, CXCR4, Vimentin, and PANCK, and highlighted interactions between mesothelial‑like malignant cells and macrophages via MIF‑associated pathways. These findings suggest that targeting MIF‑CD74 signaling could form the basis for novel therapeutic strategies in TACC.
The findings suggest that its recurrence and metastasis may be caused by a type of mesothelial cell.
Bizonyítékszint: Számítógépes vagy elméleti. Modellből vagy adatbányászatból származó jel.
Kapcsolódó jelek
- Correction: Primary cutaneous adenoid cystic carcinoma of the right forearm: a case report and dermoscopic features
- A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug
- Adenoid cystic carcinoma (ACC)
- DAY301 | Day One Biopharmaceuticals
- Completed Studies – Adenoid Cystic Carcinoma Research Foundation