Biomarkers & Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review & Meta‑Analysis
Overexpression of EGFR was associated with worse overall mortality (HR = 1.52, P = .01).
EGFR, cyclin D1, and Bcl‑2 are proteins involved in different stages of tumorigenesis which have all been associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). In this systematic review and meta‑analysis, we aim to measure the association of each protein with survival in HNSCC.
The finding that EGFR overexpression predicts poorer overall survival in HNSCC supports its potential role as a prognostic biomarker and suggests that targeting EGFR may improve patient outcomes.
Bizonyítékszint: Korai humán adat. Kis vagy feltáró emberi adat.
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