Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators.

Rákkutatás · Endometrial cancer

Circulating biomarkers for inflammation, insulin resistance, and sex hormones may mediate the effect of obesity on endometrial cancer risk, with some overlaps in mediating pathways. Sex hormones were the most prominent mediators in postmenopausal obesity, whereas biomarkers for inflammation may play an important role in premenopausal obesity.

This nationwide retrospective cohort study linked the National Disability Database, the Korean Central Cancer Registry, and the National Health Insurance claims database to examine differences in care and outcomes among women with and without disabilities diagnosed with endometrial cancer. A total of 726 women with disabilities and 2,630 women without disabilities were included. Stage distribution at diagnosis did not differ significantly between groups; however, women with disabilities had lower rates of chemotherapy and, particularly among those with severe disabilities, lower rates of surgery. Multivariable Cox regression showed that women with disabilities had a 44% higher risk of all‑cause mortality (adjusted hazard ratio 1.44, 95% CI 1.20–1.73), with the highest risk among women with mild physical/brain disabilities (aHR 1.54, 95% CI 1.21–1.96).

Understanding how obesity contributes to endometrial cancer risk through specific biological pathways can inform prevention strategies and identify potential therapeutic targets.

Bizonyítékszint: Korai humán adat. Kis vagy feltáró emberi adat.

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