New fibroblast state reveals how lung tumors may suppress immune defenses
CHL1-expressing fibroblasts in lung tumors recruit immunosuppressive regulatory T cells via CXCL9, limiting antitumor immune responses.
Targeting the regulatory T cells drawn in by the fibroblasts could unleash the immune system and offer a promising strategy against lung cancer.
Bizonyítékszint: Állatkísérletes. Állatmodellben vizsgálták.
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